Depends on your Role.
For example, on my warrior I usually try to run one of the purple Condition Duration down Runes. Usually Blindness. Since in PvE, especially with Hero monks, you can't always depend on them clearing your blind right away like you would in PvP.
Though my Rit because he uses a wide variety of builds just has a rune for each stat (Minor) and a Superior Vigor.
I run that sort of setup in PvE on my Acolyte Jin on my Monk. There Jin is set up as a R/Rt Beastmaster/Spirit Lord thing. The extra energy really helps. And I don't need to worry about things like Dazed or Blind.
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Niva Reikan: Warrior/Monk, Kurzick Champion
Arcturus Highwind: Paragon/Ranger
Pet: ROUS
Walker Tam: Warrior, Defender of Ascalon in Training
Nikolia Vasburg: Ritualist/Necromancer
